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Kavinace 60c
Kavinace 60c by NeuroScience
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Kavinace 60c

Manufacturer:  NeuroScience
Part Number:NS0014
Your Price: $50.00
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Kavinace 60c by NeuroScience

Contains a blend of ingredients involved in the synthesis and activity of GABA, a neurotransmitter important for sleep*

GABA is the primary inhibitory neurotransmitter in the brain, meaning its central role is to balance excitability of neurons (1). Because of its function, GABA is important for promoting sleep, calm, and managing stress (2-4). Stress is thought to alter GABA synthesis and activity by affecting the expression of GABA-synthesizing enzymes and receptors (5).

Ingredients such as taurine and vitamin B6 are important for glutamate-GABA balance.* High glutamate can damage neurons, alter cellular homeostasis, and cause mitochondrial dysfunction, which can ultimately lead to cell death (6). Taurine demonstrates GABA-A agonist activity and protects neurons and mitochondria against glutamate-induced damage (6, 7).* Active form of vitamin B6 is important for the synthesis of GABA as it is a required cofactor for glutamate decarboxylase, the enzyme responsible for converting glutamate to GABA (8-10).*

References:

1. Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81.
2. Mohler H. Neuropharmacology. 2012;62(1):42-53.
3. Saper C, et al. Nature. 2005;437(7063):1257-63.
4. Mody I and Maguire J. Front Cell Neurosci. 2012;6:4.
5. Maguire J. Front Cell Neurosci. 2014;8:157.
6. Ye H, et al. Can J Neurol Sci. 2013;40(5):628-34.
7. Kletke O, et al. PLoS One. 2013;8(4):e61733.
8. Rowley N, et al. Neurochem Int. 2012;61(4):546-58.
9. Martin D. Cell Mol Neurobiol. 1987;7(3):237-53.
10. Mukherjee T, et al. Biochim Biophys Acta. 2011;1814(11):1585-96.

Recommendation:
Take 1-2 capsules one to two times daily or as directed by your healthcare provider. Suggested at bedtime.

If you are pregnant or nursing, consult your healthcare provider before use.

Serving Size: 2 Capsules
Servings Per Container: 30

Amount Per Serving:
Vitamin B6 ... 2mg
(as pyridoxal 5-phosphate)
Proprietary Blend ... 950mg
Taurine and 4-amino-3-phenylbutyric acid HCl

Other Ingredients: Microcrystalline cellulose, Vegetable capsule (Hypromellose, water), and Magnesium stearate (vegetable source).

Customer Reviews

1 Stars
Didn''t work for me
Customer service from Covenant was terrific! Sadly, the product didn''t seem to help. Didn''t relax or sleep better, and it seemed to cause heart palpitations. Just not the right formula for me.
Did you find this helpful?  29 of 43 Found Helpful
Reviewed by:  from Phoenix, AZ. on 3/21/2015
1/5
5 Stars
RN
So I was recently diagnosed with early menopause and was suffering from the worst insomnia of my life..I have always been a very light sleeper and struggled with this for some time...but it was extreme at this point. A friend told me about the product and I ordered it...So thankful, most nights now I get a very restful REM nights worth of sleep...not a cure all but definitely a marked improvement
Did you find this helpful?  23 of 43 Found Helpful
Reviewed by:  from Queen Creek. on 8/12/2015
5/5
5 Stars
Kavinace 60c
This product is amazing! I sleep better with it, as well as, relax through everything I need to accomplish when pressure is on. I highly recommend it to anyone who does not want typical pharmaceuticals.
Did you find this helpful?  23 of 40 Found Helpful
Reviewed by:  from Carlsbad, CA. on 7/3/2015
5/5
5 Stars
Great product
Great product, I've been sleeping much better with it.
Did you find this helpful?  22 of 41 Found Helpful
Reviewed by:  from Ashland, Oregon. on 7/2/2015
5/5

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